Well, I got the first dose of the Covid Vaccine today.

CowpokeU said:
I'm roughing it but I'm using mucinex and a rotation of Ibuprofen and tylenol. I know I'm dehydrated so I'm trying to suck down as much water as much as I can.

I'm also changing my socks lol
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You wear socks?

Hang in there and shake it off.
 
I got my first dose yesterday! I've had soreness, a headache, and been pretty tired. To be fair though, I usually have a pretty moderate immune response to the flu vaccine every year. There are ideas and theories floating around that Moderna can illicit a more intense response than Pfizer and that if you've had covid, you'll have a more intense immune response regardless of vaccine (this wouldn't be surprising as your immune system is more actively and quickly attacking the foreign protein). Water, advil / tylenol, rest and lidocaine patches for injection sites are our friends right now.

Also, I'm a biochemistry and molecular biology masters student and have been unofficially accepted to a biomedical sciences PhD program so I'm willing to answer any questions anyone might have! If I don't know the answer, I know how to research it and let you know!
 
FQ_Caroline said:
I got my first dose yesterday! I've had soreness, a headache, and been pretty tired. To be fair though, I usually have a pretty moderate immune response to the flu vaccine every year. There are ideas and theories floating around that Moderna can illicit a more intense response than Pfizer and that if you've had covid, you'll have a more intense immune response regardless of vaccine (this wouldn't be surprising as your immune system is more actively and quickly attacking the foreign protein). Water, advil / tylenol, rest and lidocaine patches for injection sites are our friends right now.

Also, I'm a biochemistry and molecular biology masters student and have been unofficially accepted to a biomedical sciences PhD program so I'm willing to answer any questions anyone might have! If I don't know the answer, I know how to research it and let you know!
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Can I take tylenol & Aleve, drink whiskey, slam a 40 oz Mickey's with the lidocaine patch pressed in on my tukus hole?
 
tinp said:
Can I take tylenol & Aleve, drink whiskey, slam a 40 oz Mickey's with the lidocaine patch pressed in on my tukus hole?
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Of course. You're being a dick, per usual, but you can always do all of those things. I wouldn't recommend all of them but that's beside the point
 
FQ_Caroline said:
I got my first dose yesterday! I've had soreness, a headache, and been pretty tired. To be fair though, I usually have a pretty moderate immune response to the flu vaccine every year. There are ideas and theories floating around that Moderna can illicit a more intense response than Pfizer and that if you've had covid, you'll have a more intense immune response regardless of vaccine (this wouldn't be surprising as your immune system is more actively and quickly attacking the foreign protein). Water, advil / tylenol, rest and lidocaine patches for injection sites are our friends right now.

Also, I'm a biochemistry and molecular biology masters student and have been unofficially accepted to a biomedical sciences PhD program so I'm willing to answer any questions anyone might have! If I don't know the answer, I know how to research it and let you know!
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If I may, the receptor that the virus targets ... what is its normal purpose, in layman's terms? Thank you.
 
batchaps4me said:
If I may, the receptor that the virus targets ... what is its normal purpose, in layman's terms? Thank you.
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This may be a longer answer but let me know if any of it doesn't make any sense: so, because it's an mRNA vaccine, it is teaching your body how to make protein that creates antibodies to illicit an immune response. This protein to antibody creation is nothing new and something your body does both regularly and naturally. Basically, the antibodies are searching for and then kinda flagging whatever foreign virus or bacteria has found its way into your body. You may have heard of the "adaptive" immune system. Antibodies are part of that because they are able to learn and recognize and destroy pathogens. The covid vaccine takes advantage of that natural process in your body by introducing molecular fragments of the spike proteins found on covid's coating. After getting the vaccine, your body "adapts" to this new foreign protein and learns how to recognize and destroy the covid protein. If you were to be exposed to the covid proteins again, your body would be more equipped to notice and kill that protein again. In the simplest terms I can think of right now, it's a synthetic way to create natural immunity. I hope that answers your question!
 
FQ_Caroline said:
This may be a longer answer but let me know if any of it doesn't make any sense: so, because it's an mRNA vaccine, it is teaching your body how to make protein that creates antibodies to illicit an immune response. This protein to antibody creation is nothing new and something your body does both regularly and naturally. Basically, the antibodies are searching for and then kinda flagging whatever foreign virus or bacteria has found its way into your body. You may have heard of the "adaptive" immune system. Antibodies are part of that because they are able to learn and recognize and destroy pathogens. The covid vaccine takes advantage of that natural process in your body by introducing molecular fragments of the spike proteins found on covid's coating. After getting the vaccine, your body "adapts" to this new foreign protein and learns how to recognize and destroy the covid protein. If you were to be exposed to the covid proteins again, your body would be more equipped to notice and kill that protein again. In the simplest terms I can think of right now, it's a synthetic way to create natural immunity. I hope that answers your question!
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That is excellent information that was easy to understand. You answered most of my questions but I still have one. Please forgive me, but I am curious as to the purpose of the human cell receptor to which the virus protein attaches. It must have a normal function/purpose in my way of thinking. This leads me to two questions:
1. Does the virus prevent that receptor from functioning normally for the duration of the infection ...attach, replicate and remain attached or does it attach, trigger and detach to replicate? I assume the latter and then the virus attaches to another receptor and repeats.
2. Any chance that the vaccine will prohibit those receptors from functioning normally by destroying similar proteins?
 
batchaps4me said:
That is excellent information that was easy to understand. You answered most of my questions but I still have one. Please forgive me, but I am curious as to the purpose of the human cell receptor to which the virus protein attaches. It must have a normal function/purpose in my way of thinking. This leads me to two questions:
1. Does the virus prevent that receptor from functioning normally for the duration of the infection ...attach, replicate and remain attached or does it attach, trigger and detach to replicate? I assume the latter and then the virus attaches to another receptor and repeats.
2. Any chance that the vaccine will prohibit those receptors from functioning normally by destroying similar proteins?
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I'll do my best again:
1. Covid is believed to bind to ACE2, angiotensin-converting enzyme 2. This receptor breaks apart angiotensin protein to regulate a number of bodily functions, like stabilizing blood pressure. Covid's spike proteins use the receptor to invade healthy cells. Once attached to and inside cells, the virus replicates inside the cell and then starts causing problems throughout the body.
2. Based on my understanding, targeting the ACE2 receptor is being researched more to look at drug therapeutics rather than vaccination options. It looks like scientists are not in total agreement about what it means that coronavirus exploits ACE2. Some people think that adding more ACE2 into the body, through drug therapeutics, the virus will become confused and bind to the drug rather than onto your cells. Then it can't replicate and spread, ideally. But no, the vaccine will not prohibit ACE2 receptors from functioning normally. Think about pathogens (virus) and antibodies (your body's immune response) as like a lock-and-key. Specific antibodies bind to specific pathogens.
 
FQ_Caroline said:
I'll do my best again:
1. Covid is believed to bind to ACE2, angiotensin-converting enzyme 2. This receptor breaks apart angiotensin protein to regulate a number of bodily functions, like stabilizing blood pressure. Covid's spike proteins use the receptor to invade healthy cells. Once attached to and inside cells, the virus replicates inside the cell and then starts causing problems throughout the body.
2. Based on my understanding, targeting the ACE2 receptor is being researched more to look at drug therapeutics rather than vaccination options. It looks like scientists are not in total agreement about what it means that coronavirus exploits ACE2. Some people think that adding more ACE2 into the body, through drug therapeutics, the virus will become confused and bind to the drug rather than onto your cells. Then it can't replicate and spread, ideally. But no, the vaccine will not prohibit ACE2 receptors from functioning normally. Think about pathogens (virus) and antibodies (your body's immune response) as like a lock-and-key. Specific antibodies bind to specific pathogens.
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Thank you so very much. I understand and appreciate your time and effort. I hope to leave you with a smile when I tell you that my Dad spent a lot of his life looking at me, shaking his head, and mumbling, "There's nothing worse than a curious idiot." :)
 
batchaps4me said:
Thank you so very much. I understand and appreciate your time and effort. I hope to leave you with a smile when I tell you that my Dad spent a lot of his life looking at me, shaking his head, and mumbling, "There's nothing worse than a curious idiot." :)
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No problem at all! I actually really enjoyed it. It put my studies, critical thinking and research skills to use!
 
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